Positive regulation of protein catabolic process in the vacuole

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein catabolic process in the vacuole pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1, RFC1_S368, and EDC3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein catabolic process in the vacuole activity versus RFC1 in PDAC (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RFC1 →	-0.247	-0.069	<.001	<.001	3	6
LUAD	RFC1_S368 →	-0.578	-0.083	<.001	<.001	3	6
GBM	EDC3 →	-0.181	-0.083	.005	.004	2	7
OV	RCOR2_S63 →	-1.022	-0.104	.002	<.001	3	6
GBM	ATAD2_S342 →	-0.751	-0.095	.001	.003	3	6
LSCC	POMK →	-0.583	-0.097	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904352 vs RFC1 — PDAC

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