Positive regulation of protein catabolic process in the vacuole

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein catabolic process in the vacuole pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC7A5, ASAH1, and PTBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein catabolic process in the vacuole activity versus SLC7A5 in HNSC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLC7A5 →	-0.895	-0.163	.007	.001	3	5
LSCC	ASAH1 →	+0.520	+0.421	<.001	<.001	3	4
LSCC	PTBP1 →	-0.447	-0.483	<.001	.001	3	4
BRCA	AGTR1 →	+1.595	+0.578	.003	.001	3	4
LSCC	TMEM200A →	+0.636	+0.362	.001	.006	2	5
CCRCC	PHYHIP →	+0.336	+0.156	.008	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904352 vs SLC7A5 — HNSC

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