Positive regulation of protein catabolic process in the vacuole

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein catabolic process in the vacuole pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFAP299, MRPL38, and GBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein catabolic process in the vacuole activity versus CFAP299 in BONE (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CFAP299 →	+1.260	+1.954	.006	<.001	3	5
LIVER	MRPL38 →	-0.677	-1.403	.004	.002	3	5
PANCREAS	GBP1 →	+2.316	+1.465	<.001	.001	3	5
SKIN	HTRA1 →	+2.351	+0.793	.005	.008	3	5
OVARY	SLC25A19 →	-0.630	-1.062	<.001	<.001	3	5
LARGE_INTESTINE	CCDC80 →	+2.246	+0.871	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904352 vs CFAP299 — BONE

Explore this scatter interactively →