Negative regulation of protein catabolic process in the vacuole

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein catabolic process in the vacuole pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHN1, CMTM3, and C12orf60, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein catabolic process in the vacuole activity versus PLEKHN1 in BLOOD_Myeloma (Pearson r = -0.93).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PLEKHN1 →	-1.152	-0.110	.002	.001	3	2
LUNG_NSCLC_LUAD	CMTM3 →	-3.652	-0.305	.003	.002	3	2
LUNG_NSCLC_LUAD	C12orf60 →	-0.577	-0.305	.001	.002	3	2
LUNG_NSCLC_LUAD	CLIC1 →	-0.582	-0.305	.006	.002	3	2
LUNG_NSCLC_LUAD	TCF7 →	-2.622	-0.305	.001	.002	3	1
LUNG_NSCLC_LUAD	HIVEP3 →	-2.309	-0.305	.005	.002	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904351 vs PLEKHN1 — BLOOD_Myeloma

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