Regulation of protein catabolic process in the vacuole

Across TCGA patient cohorts, RNA activity of the Regulation of protein catabolic process in the vacuole pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRP2, DCLRE1C, and PRKCA-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein catabolic process in the vacuole activity versus LRP2 in BRCA (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LRP2 →	+2.605	+0.480	<.001	.003	3	4
CCRCC	DCLRE1C →	-0.228	-0.210	<.001	<.001	3	4
BRCA	PRKCA-AS1 →	-0.018	-0.412	.001	.005	3	4
GBM	AGTPBP1 →	-0.551	-0.156	.002	.002	3	4
GBM	DDX50P1 →	-0.281	-0.116	<.001	.002	3	4
LUAD	MATN1-AS1 →	-0.320	-0.201	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904350 vs LRP2 — BRCA

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