Regulation of protein catabolic process in the vacuole

Across TCGA cell cohorts, RNA activity of the Regulation of protein catabolic process in the vacuole pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX6B1, SUMF2, and TMEM106B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COX6B1 grouped by Regulation of protein catabolic process in the vacuole-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	COX6B1 →	-0.417	-0.870	.004	.002	3	4
CNS	SUMF2 →	+0.661	+0.802	.007	.007	3	4
CNS	TMEM106B →	+0.914	+1.085	.005	.001	3	3
CNS	PCSK4 →	+0.939	+1.226	.001	<.001	3	3
CNS	TMEM214 →	+0.557	+0.871	.002	<.001	3	3
CNS	PRRG1 →	+1.003	+0.956	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COX6B1 by Regulation of protein catabolic process in the vacuole activity — CNS

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