Regulation of protein catabolic process in the vacuole

Across TCGA cell cohorts, RNA activity of the Regulation of protein catabolic process in the vacuole pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HPS3, HIBADH, and SLC9A6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein catabolic process in the vacuole activity versus HPS3 in LUNG_NSCLC_LUAD (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HPS3 →	+0.588	+0.790	.001	<.001	3	5
OESOPHAGUS	HIBADH →	+1.313	+1.135	<.001	<.001	3	4
BONE	SLC9A6 →	+0.667	+0.884	<.001	.006	3	4
SOFT_TISSUE	PELI3 →	+0.846	+0.942	.004	.003	3	4
OVARY	FGFR3 →	-2.137	-1.012	<.001	<.001	3	4
LUNG_SCLC	BCL11A →	-1.731	-0.706	.008	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904350 vs HPS3 — LUNG_NSCLC_LUAD

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