Regulation of dopaminergic neuron differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of dopaminergic neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1QC, TIAM1_S358, and SLCO4A1_S43, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dopaminergic neuron differentiation activity versus C1QC in OV (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C1QC →	+0.673	+0.087	<.001	<.001	3	5
LSCC	TIAM1_S358 →	+0.499	+0.079	<.001	.001	3	5
PDAC	SLCO4A1_S43 →	+2.402	+0.114	.001	<.001	3	4
CCRCC	C1QB →	+0.560	+0.095	<.001	<.001	3	4
CCRCC	CD14 →	+0.366	+0.084	<.001	<.001	3	4
OV	CTHRC1 →	+0.836	+0.070	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904338 vs C1QC — OV

Explore this scatter interactively →