Regulation of dopaminergic neuron differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of dopaminergic neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MN1, TNIK, and LDLRAD4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dopaminergic neuron differentiation activity versus MN1 in PDAC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MN1 →	+0.459	+0.445	.001	.009	3	4
UCEC	TNIK →	+0.814	+0.474	.002	.003	3	3
BRCA	LDLRAD4 →	+0.903	+0.501	<.001	.003	3	3
GBM	RMDN2 →	+0.545	+0.888	<.001	<.001	3	3
GBM	TACC3 →	-0.572	-0.630	.001	<.001	3	3
GBM	ERCC4 →	+0.276	+0.662	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904338 vs MN1 — PDAC

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