Regulation of dopaminergic neuron differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of dopaminergic neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBWD5, HOXA1, and UNC93B1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CBWD5 grouped by Regulation of dopaminergic neuron differentiation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CBWD5 →	-0.688	-1.168	.004	.002	3	4
LUNG_SCLC	HOXA1 →	+1.629	+0.964	.002	.005	3	4
LUNG_SCLC	UNC93B1 →	+1.803	+1.240	.003	.001	3	4
LUNG_NSCLC_LUAD	EIF4A3 →	-0.563	-0.785	.001	.007	3	4
LUNG_NSCLC_LUAD	CLVS1 →	-0.186	-0.819	.008	.002	3	4
SOFT_TISSUE	ABCA2 →	+1.135	+1.257	.003	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CBWD5 by Regulation of dopaminergic neuron differentiation activity — OESOPHAGUS

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