Response to forskolin

Across TCGA patient cohorts, RNA activity of the Response to forskolin pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SGCD, DAB2IP_S995, and STOML1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to forskolin activity versus SGCD in BRCA (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SGCD →	-0.435	-0.038	.003	.001	3	4
LSCC	DAB2IP_S995 →	+0.727	+0.065	<.001	<.001	3	4
OV	STOML1 →	+0.391	+0.068	.006	<.001	3	4
HNSC	FZD7 →	-0.652	-0.048	.002	.007	3	4
PDAC	DPYSL3 →	-0.412	-0.046	<.001	.005	3	4
LSCC	SSH1_S1042 →	+0.668	+0.053	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904321 vs SGCD — BRCA

Explore this scatter interactively →