Response to forskolin

Across TCGA patient cohorts, RNA activity of the Response to forskolin pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTUS1, MCM10, and ZNF209P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to forskolin activity versus MTUS1 in OV (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MTUS1 →	+0.810	+0.983	<.001	<.001	3	4
OV	MCM10 →	-0.700	-0.714	.008	.005	3	4
LSCC	ZNF209P →	+0.072	+0.528	.003	.005	3	4
UCEC	SRSF10P1 →	+0.715	+0.620	.001	.009	3	3
GBM	SLC1A1 →	+0.646	+0.487	.004	.003	3	3
GBM	CBR4 →	+0.330	+0.462	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904321 vs MTUS1 — OV

Explore this scatter interactively →