Response to forskolin

Across TCGA cell cohorts, RNA activity of the Response to forskolin pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DMXL2, MRAS, and DCAF16, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DMXL2 grouped by Response to forskolin-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DMXL2 →	+1.765	+0.869	.004	<.001	3	3
BLOOD_Leukemia	MRAS →	+2.302	+0.943	<.001	<.001	3	3
SOFT_TISSUE	DCAF16 →	-0.866	-0.966	.006	.007	3	3
BLOOD_Myeloma	TMEM97 →	+1.181	+1.272	.006	.004	3	3
BLOOD_Myeloma	SMYD5 →	+0.757	+1.324	<.001	.002	3	3
BLOOD_Myeloma	TMEM187 →	-0.881	-1.210	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DMXL2 by Response to forskolin activity — BLOOD_Leukemia

Explore this box plot interactively →