Response to forskolin

Across TCGA cell cohorts, RNA activity of the Response to forskolin pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXOSC8, GNAI1, and CTAGE8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to forskolin activity versus EXOSC8 in OESOPHAGUS (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EXOSC8 →	-1.284	-1.507	.005	.001	3	5
OVARY	GNAI1 →	+1.677	+1.199	.001	.001	3	4
LUNG_SCLC	CTAGE8 →	+1.099	+0.954	.004	.001	3	4
OESOPHAGUS	NUFIP1 →	-1.002	-1.407	<.001	.002	3	4
BLOOD_Lymphoma	TLR6 →	-2.166	-1.409	<.001	<.001	3	4
URINARY_TRACT	ARID5B →	+2.229	+0.491	<.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904321 vs EXOSC8 — OESOPHAGUS

Explore this scatter interactively →