Regulation of ERAD pathway

Across TCGA cell cohorts, RNA activity of the Regulation of ERAD pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KHSRP, THOP1, and CDC27, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ERAD pathway activity versus KHSRP in PANCREAS (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KHSRP →	+1.177	+0.338	<.001	.002	3	7
PANCREAS	THOP1 →	+0.965	+0.333	<.001	<.001	3	6
PANCREAS	CDC27 →	+0.903	+0.382	<.001	.001	3	6
OVARY	POLR2E →	+0.864	+0.320	.006	<.001	3	6
BLOOD_Leukemia	NCS1 →	+1.855	+0.194	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	ABHD10 →	+1.123	+0.258	.003	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904292 vs KHSRP — PANCREAS

Explore this scatter interactively →