Pericyte cell differentiation

Across TCGA patient cohorts, RNA activity of the Pericyte cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLC1, MIR8078, and IRAG1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pericyte cell differentiation activity versus DLC1 in BRCA (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DLC1 →	+0.616	+0.503	<.001	.005	3	3
BRCA	MIR8078 →	-0.547	-0.428	.003	.009	3	3
BRCA	IRAG1 →	+0.510	+0.407	.002	.006	3	3
CCRCC	FMO2 →	+1.593	+0.214	<.001	.005	3	3
LUAD	DPYSL3 →	+0.593	+0.481	.001	.002	3	3
CCRCC	LMO2 →	+0.384	+0.210	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904238 vs DLC1 — BRCA

Explore this scatter interactively →