Positive regulation of adipose tissue development

Across TCGA patient cohorts, RNA activity of the Positive regulation of adipose tissue development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCOA2, RNU6-204P, and JADE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of adipose tissue development activity versus NCOA2 in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NCOA2 →	+0.810	+0.736	<.001	<.001	3	4
UCEC	RNU6-204P →	+0.863	+0.140	.002	.004	3	4
BRCA	JADE1 →	+0.464	+0.636	.008	.001	2	5
LSCC	MT2P1 →	-0.490	-0.234	<.001	.003	3	3
BRCA	CFAP91 →	+0.634	+0.589	.003	<.001	3	3
BRCA	KLHL14 →	+0.524	+0.618	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904179 vs NCOA2 — BRCA

Explore this scatter interactively →