Regulation of adipose tissue development

Across TCGA patient cohorts, RNA activity of the Regulation of adipose tissue development pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_S368, RPL7, and SNX9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of adipose tissue development activity versus RFC1_S368 in LUAD (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RFC1_S368 →	-0.633	-0.054	<.001	<.001	3	7
BRCA	RPL7 →	-0.191	-0.058	.004	<.001	3	7
OV	SNX9 →	+0.322	+0.064	.002	<.001	3	7
BRCA	ATXN2L →	-0.231	-0.063	<.001	<.001	3	7
BRCA	TNS2_S102 →	+0.783	+0.087	<.001	<.001	3	7
BRCA	CRYL1 →	+0.475	+0.078	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904177 vs RFC1_S368 — LUAD

Explore this scatter interactively →