Regulation of adipose tissue development

Across TCGA patient cohorts, RNA activity of the Regulation of adipose tissue development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMA1, CDKN1A, and SH3BGRL2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of adipose tissue development activity versus CMA1 in LUAD (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CMA1 →	+0.606	+0.433	.004	.003	3	4
GBM	CDKN1A →	-0.722	-0.203	.005	<.001	3	4
HNSC	SH3BGRL2 →	+0.911	+0.694	.005	<.001	3	3
HNSC	MTND5P25 →	+0.709	+0.408	.002	.004	3	3
COAD	ATXN1-AS1 →	+0.441	+0.482	<.001	.005	3	3
LSCC	MYO5A →	-0.495	-0.231	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904177 vs CMA1 — LUAD

Explore this scatter interactively →