Axonemal central apparatus assembly

Across TCGA patient cohorts, RNA activity of the Axonemal central apparatus assembly pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR38, NHLRC4, and SH3BP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axonemal central apparatus assembly activity versus WDR38 in LSCC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDR38 →	+0.910	+0.467	<.001	<.001	3	3
LSCC	NHLRC4 →	+0.388	+0.358	<.001	<.001	3	3
LSCC	SH3BP1 →	-0.329	-0.211	.002	.004	3	2
LSCC	SPEF1 →	+0.660	+0.352	<.001	<.001	3	2
OV	DYDC2 →	+1.396	+0.223	.002	.002	2	3
LSCC	LGSN →	+0.769	+0.289	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904158 vs WDR38 — LSCC

Explore this scatter interactively →