"Regulation of retrograde protein transport, ER to cytosol"

Across TCGA cell cohorts, RNA activity of the "Regulation of retrograde protein transport, ER to cytosol" pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C10orf95, WNT5B, and POLA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C10orf95 grouped by "Regulation of retrograde protein transport, ER to cytosol"-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	C10orf95 →	+0.335	+1.034	.002	.008	3	4
OVARY	WNT5B →	-1.726	-0.901	.001	<.001	3	4
BLOOD_Leukemia	POLA1 →	+1.061	+1.145	<.001	.004	3	4
BLOOD_Leukemia	STMN1 →	+0.988	+0.937	.004	.003	3	4
BONE	SAFB →	+0.810	+1.463	.006	.008	3	4
BLOOD_Leukemia	SRP68 →	+0.434	+1.239	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C10orf95 by "Regulation of retrograde protein transport, ER to cytosol" activity — KIDNEY

Explore this box plot interactively →