Response to vasopressin

Across TCGA patient cohorts, RNA activity of the Response to vasopressin pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TMOD2, WIPF1, and PPP1R18_S145, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to vasopressin activity versus TMOD2 in BRCA (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TMOD2 →	-0.299	-0.043	<.001	<.001	3	6
HNSC	WIPF1 →	-0.285	-0.052	<.001	.004	3	6
OV	PPP1R18_S145 →	-0.418	-0.040	.008	.004	3	6
OV	GIMAP8 →	-0.446	-0.057	<.001	<.001	3	6
GBM	INPP5D →	-0.355	-0.095	.001	<.001	3	6
COAD	INPP4A →	-0.225	-0.055	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904116 vs TMOD2 — BRCA

Explore this scatter interactively →