Response to vasopressin

Across TCGA patient cohorts, RNA activity of the Response to vasopressin pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IQANK1, PLEKHH1, and NIPA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to vasopressin activity versus IQANK1 in OV (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IQANK1 →	+0.758	+0.608	.004	.006	3	5
GBM	PLEKHH1 →	+0.826	+0.890	.001	<.001	3	4
GBM	NIPA1 →	+0.442	+0.781	<.001	<.001	3	4
CCRCC	SNHG7 →	-0.459	-0.636	<.001	<.001	3	4
HNSC	TMOD2 →	-0.543	-0.711	.004	<.001	3	3
HNSC	KIAA1671 →	+0.412	+0.389	.008	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904116 vs IQANK1 — OV

Explore this scatter interactively →