Response to vasopressin

Across TCGA cell cohorts, RNA activity of the Response to vasopressin pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RANGAP1, SCNN1G, and GPAT4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RANGAP1 grouped by Response to vasopressin-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RANGAP1 →	-0.311	-1.368	.003	.004	3	7
LUNG_NSCLC_LUAD	SCNN1G →	-0.265	-0.794	.002	.003	3	5
CNS	GPAT4 →	+0.107	+0.615	.009	.007	3	5
SOFT_TISSUE	AHI1 →	+0.315	+1.238	.001	<.001	3	4
OVARY	ADCY6 →	-0.384	-1.104	.001	.005	2	5
LARGE_INTESTINE	SLIT1 →	+0.242	+1.020	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RANGAP1 by Response to vasopressin activity — STOMACH

Explore this box plot interactively →