Response to vasopressin

Across TCGA cell cohorts, RNA activity of the Response to vasopressin pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMURF1, IKZF5, and ANKRD26, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMURF1 grouped by Response to vasopressin-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SMURF1 →	+1.193	+0.931	.005	.004	3	5
BLOOD_Leukemia	IKZF5 →	+0.744	+1.388	.005	.001	3	5
BLOOD_Leukemia	ANKRD26 →	+0.723	+1.240	<.001	<.001	3	5
KIDNEY	RAB10 →	+0.575	+1.416	.005	<.001	3	5
BLOOD_Lymphoma	HUS1 →	+0.940	+2.299	.002	<.001	3	4
LUNG_SCLC	MAP3K14 →	+1.438	+1.459	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMURF1 by Response to vasopressin activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →