Response to aldosterone

Across TCGA patient cohorts, RNA activity of the Response to aldosterone pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIGLEC22P, TARDBP, and KMO, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to aldosterone activity versus SIGLEC22P in GBM (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SIGLEC22P →	+0.696	+0.189	<.001	<.001	3	6
GBM	TARDBP →	-0.314	-0.145	<.001	<.001	3	5
UCEC	KMO →	+0.602	+0.470	.001	.004	3	5
OV	IKZF3 →	+0.885	+0.510	<.001	.002	3	5
GBM	NFAM1 →	+0.766	+0.154	<.001	<.001	3	5
PDAC	ZNF638 →	-0.233	-0.328	.008	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904044 vs SIGLEC22P — GBM

Explore this scatter interactively →