Response to aldosterone

Across TCGA cell cohorts, RNA activity of the Response to aldosterone pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPC2, USP18, and RPL24, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NPC2 grouped by Response to aldosterone-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NPC2 →	-0.944	-1.035	.003	.001	3	4
PANCREAS	USP18 →	-1.111	-0.830	.003	.004	3	3
CNS	RPL24 →	+0.775	+0.794	.004	<.001	3	3
OVARY	DNAJB2 →	-1.114	-1.167	.004	<.001	3	3
OVARY	RPL22L1 →	+1.268	+0.791	.004	.005	3	3
URINARY_TRACT	SH3BGRL →	-1.787	-1.371	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NPC2 by Response to aldosterone activity — CNS

Explore this box plot interactively →