Response to aldosterone

Across TCGA cell cohorts, RNA activity of the Response to aldosterone pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CACHD1, USP51, and ZBED1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to aldosterone activity versus CACHD1 in STOMACH (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CACHD1 →	+1.998	+0.281	.004	.005	3	5
OVARY	USP51 →	+1.056	+0.266	.002	.003	3	4
BLOOD_Leukemia	ZBED1 →	+0.658	+0.129	.002	.003	3	4
LARGE_INTESTINE	ZFYVE9 →	+0.532	+0.158	.007	.001	3	4
OVARY	MGLL →	-3.901	-0.378	<.001	.001	3	4
BLOOD_Lymphoma	CYP51A1 →	+1.152	+0.226	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904044 vs CACHD1 — STOMACH

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