Response to aldosterone

Across TCGA cell cohorts, RNA activity of the Response to aldosterone pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTPRC, AIFM1, and NOC2L, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to aldosterone activity versus PTPRC in LUNG_NSCLC_LUAD (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PTPRC →	+2.033	+0.238	<.001	<.001	3	13
BONE	AIFM1 →	+1.088	+0.265	<.001	<.001	3	11
STOMACH	NOC2L →	+0.651	+0.273	.003	.001	3	9
BONE	ELAVL1 →	+0.538	+0.236	.003	.001	3	9
CNS	TUBB4B →	-1.566	-0.253	<.001	<.001	3	8
BONE	SRSF7 →	+0.691	+0.234	.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904044 vs PTPRC — LUNG_NSCLC_LUAD

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