Positive regulation of epithelial cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of epithelial cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSN, RBM18, and MAP4K3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of epithelial cell apoptotic process activity versus GSN in LUNG_NSCLC_LUAD (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GSN →	+1.761	+0.286	.002	<.001	3	8
LUNG_NSCLC_LUAD	RBM18 →	+0.468	+0.192	.003	.002	3	6
SOFT_TISSUE	MAP4K3 →	+0.812	+0.409	.007	.007	3	6
LUNG_NSCLC_LUAD	SON →	+0.663	+0.209	.002	<.001	3	6
SKIN	MARCKSL1 →	+1.823	+0.150	.002	.006	3	6
SKIN	SRRT →	+0.631	+0.133	.009	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904037 vs GSN — LUNG_NSCLC_LUAD

Explore this scatter interactively →