Negative regulation of epithelial cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of epithelial cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FHL2, HLX, and SLC2A3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of epithelial cell apoptotic process activity versus FHL2 in GBM (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FHL2 →	+0.427	+0.102	.008	<.001	3	5
GBM	HLX →	+0.279	+0.109	.005	.004	3	5
GBM	SLC2A3 →	+1.118	+0.164	<.001	<.001	3	4
LSCC	COTL1 →	+0.381	+0.122	<.001	.004	3	3
GBM	FAH →	+0.412	+0.125	.003	.004	3	3
LSCC	GALNS →	+0.481	+0.149	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904036 vs FHL2 — GBM

Explore this scatter interactively →