Negative regulation of epithelial cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of epithelial cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT18, SPINT2, and C2orf15, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of epithelial cell apoptotic process activity versus KRT18 in LUNG_SCLC (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KRT18 →	+4.265	+0.451	<.001	<.001	2	7
BREAST	SPINT2 →	+2.769	+0.268	.002	.002	3	6
LUNG_SCLC	C2orf15 →	+2.253	+0.288	<.001	.004	3	6
LUNG_SCLC	LLGL2 →	+2.195	+0.479	<.001	<.001	3	6
LUNG_SCLC	CDH1 →	+4.812	+0.464	<.001	<.001	3	6
BREAST	CNTNAP1 →	-1.615	-0.247	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904036 vs KRT18 — LUNG_SCLC

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