Negative regulation of epithelial cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of epithelial cell apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KRT8, KRT18, and NAA15, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of epithelial cell apoptotic process activity versus KRT8 in SOFT_TISSUE (Pearson r = 0.82).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRT8 →	+5.263	+0.332	<.001	<.001	3	17
SOFT_TISSUE	KRT18 →	+5.614	+0.399	<.001	<.001	3	11
OVARY	NAA15 →	-0.856	-0.194	.002	<.001	3	6
LUNG_SCLC	KRT19 →	+4.239	+0.443	<.001	<.001	3	6
LUNG_SCLC	AK6 →	-1.256	-0.409	<.001	<.001	3	5
OVARY	CLUH →	-1.431	-0.222	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904036 vs KRT8 — SOFT_TISSUE

Explore this scatter interactively →