Epithelial cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Epithelial cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAAO, MCUB, and MAPK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cell apoptotic process activity versus HAAO in BLOOD_Leukemia (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HAAO →	+1.977	+0.247	.002	.004	3	4
OVARY	MCUB →	+1.318	+1.030	.001	.009	3	4
UPPER_AERODIGESTIVE_TRACT	MAPK1 →	+1.242	+1.391	.008	.002	2	5
UPPER_AERODIGESTIVE_TRACT	TMEM165 →	+0.908	+1.573	.006	<.001	3	4
OESOPHAGUS	SCARB2 →	+1.330	+1.282	.001	.004	3	4
UPPER_AERODIGESTIVE_TRACT	CFLAR →	+2.505	+1.728	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904019 vs HAAO — BLOOD_Leukemia

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