Positive regulation of vasculature development

Across TCGA cell cohorts, RNA activity of the Positive regulation of vasculature development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYOF, FAM117B, and BEND3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vasculature development activity versus MYOF in OESOPHAGUS (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MYOF →	+1.454	+0.245	.009	.003	3	6
BLOOD_Leukemia	FAM117B →	-0.947	-0.288	<.001	<.001	3	6
OVARY	BEND3 →	-0.782	-0.240	.003	.003	3	6
BONE	EMP1 →	+3.765	+0.299	.006	.002	3	6
SOFT_TISSUE	CDC25A →	-1.467	-0.182	.001	.003	3	5
BONE	RCC1 →	-1.308	-0.297	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904018 vs MYOF — OESOPHAGUS

Explore this scatter interactively →