Response to Thyroglobulin triiodothyronine

Across TCGA patient cohorts, RNA activity of the Response to Thyroglobulin triiodothyronine pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX21_S121, KANK2, and RPL5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to Thyroglobulin triiodothyronine activity versus DDX21_S121 in GBM (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DDX21_S121 →	-0.284	-0.071	.001	.001	3	5
BRCA	KANK2 →	+0.359	+0.070	<.001	<.001	3	5
BRCA	RPL5 →	-0.222	-0.081	<.001	<.001	3	5
BRCA	LARP1 →	-0.147	-0.058	.001	<.001	3	5
HNSC	CDC26_S42 →	-0.166	-0.048	.002	.007	3	5
OV	RPS5 →	-0.277	-0.086	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904016 vs DDX21_S121 — GBM

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