Positive regulation of glial cell migration

Across TCGA patient cohorts, RNA activity of the Positive regulation of glial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRATD1, ELOVL2, and TPX2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glial cell migration activity versus LRATD1 in LUAD (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LRATD1 →	-1.017	-0.503	<.001	.006	3	4
GBM	ELOVL2 →	-1.115	-0.584	.006	.005	3	4
UCEC	TPX2 →	-1.303	-0.785	<.001	.002	3	4
UCEC	GYPE →	+0.612	+0.619	.002	.007	3	4
HNSC	FBXO5 →	-0.616	-0.520	.002	.003	3	3
HNSC	PKN1 →	-0.794	-0.478	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903977 vs LRATD1 — LUAD

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