Regulation of monoatomic anion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Regulation of monoatomic anion transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GSTK1, TK1, and ABLIM2_S364, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of monoatomic anion transmembrane transport activity versus GSTK1 in COAD (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GSTK1 →	+0.386	+0.060	<.001	<.001	3	5
LUAD	TK1 →	-0.399	-0.034	<.001	.009	3	5
COAD	ABLIM2_S364 →	+0.547	+0.086	<.001	<.001	3	5
COAD	VPS36 →	+0.171	+0.050	<.001	.002	3	4
HNSC	ARHGEF37 →	+0.405	+0.063	<.001	.001	3	4
OV	TSTD1 →	+0.691	+0.059	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903959 vs GSTK1 — COAD

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