Positive regulation of receptor clustering

Across TCGA patient cohorts, RNA activity of the Positive regulation of receptor clustering pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CTHRC1, P3H1, and CCDC80, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of receptor clustering activity versus CTHRC1 in OV (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CTHRC1 →	+0.964	+0.054	<.001	<.001	3	9
PDAC	P3H1 →	+0.474	+0.084	<.001	<.001	3	8
OV	CCDC80 →	+0.798	+0.057	<.001	<.001	3	7
OV	CNN2 →	+0.596	+0.047	<.001	<.001	3	7
OV	COPZ2 →	+0.830	+0.055	<.001	<.001	3	7
OV	FN1 →	+1.015	+0.055	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903911 vs CTHRC1 — OV

Explore this scatter interactively →