Positive regulation of receptor clustering

Across TCGA patient cohorts, RNA activity of the Positive regulation of receptor clustering pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD33, SULF1, and SEMA3C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of receptor clustering activity versus CD33 in PDAC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CD33 →	+0.269	+0.410	.008	.005	3	4
UCEC	SULF1 →	+0.621	+0.452	.001	.003	3	4
UCEC	SEMA3C →	+0.846	+0.635	<.001	<.001	3	4
CCRCC	SLC22A5 →	-0.730	-0.134	.002	.005	3	4
GBM	OLR1 →	+0.637	+0.363	.005	.001	3	4
GBM	LINC00316 →	-0.148	-0.347	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903911 vs CD33 — PDAC

Explore this scatter interactively →