Positive regulation of receptor clustering

Across TCGA cell cohorts, RNA activity of the Positive regulation of receptor clustering pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPG, ISOC2, and APOB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAPG grouped by Positive regulation of receptor clustering-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CAPG →	-2.292	-0.902	.001	.004	3	4
LARGE_INTESTINE	ISOC2 →	+0.358	+0.796	.008	.005	3	4
PANCREAS	APOB →	+0.017	+1.012	.002	<.001	3	4
SOFT_TISSUE	ALOX12B →	+0.621	+1.358	.005	.004	2	5
STOMACH	KCNS3 →	+1.966	+0.971	.009	.003	3	3
CNS	CCDC153 →	+0.416	+1.040	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAPG by Positive regulation of receptor clustering activity — CNS

Explore this box plot interactively →