Positive regulation of receptor clustering

Across TCGA cell cohorts, RNA activity of the Positive regulation of receptor clustering pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMB1, HSPA5, and RCN2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of receptor clustering activity versus LAMB1 in LUNG_NSCLC_LUAD (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LAMB1 →	+1.770	+0.547	.004	.007	2	7
PANCREAS	HSPA5 →	+0.874	+1.132	.007	.005	3	4
LIVER	RCN2 →	+0.732	+0.516	.003	.004	3	4
BONE	C1orf43 →	-0.837	-0.277	.001	<.001	2	5
BLOOD_Leukemia	MCRIP2 →	-1.273	-0.807	.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	WTIP →	+1.162	+0.210	.008	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903911 vs LAMB1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →