Regulation of receptor clustering

Across TCGA cell cohorts, RNA activity of the Regulation of receptor clustering pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED1, SERPINE2, and ITM2B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of receptor clustering activity versus TMED1 in SKIN (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TMED1 →	+0.696	+0.271	.008	.004	3	6
SKIN	SERPINE2 →	+4.359	+0.314	.001	.002	3	5
SKIN	ITM2B →	+0.927	+0.212	<.001	.002	3	4
SKIN	THBS1 →	+3.895	+0.279	.002	.002	3	4
SKIN	AMOTL1 →	+0.692	+0.203	.005	.003	3	4
SKIN	DAG1 →	+1.277	+0.258	.007	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903909 vs TMED1 — SKIN

Explore this scatter interactively →