Negative regulation of IRE1-mediated unfolded protein response

Across TCGA patient cohorts, RNA activity of the Negative regulation of IRE1-mediated unfolded protein response pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZC3H14_S620, TOP1, and PABPC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of IRE1-mediated unfolded protein response activity versus ZC3H14_S620 in OV (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZC3H14_S620 →	-0.739	-0.032	<.001	.002	3	8
LUAD	TOP1 →	-0.359	-0.035	.001	.005	2	8
HNSC	PABPC1 →	-0.233	-0.069	.001	.002	3	7
BRCA	TNS2_S120 →	+0.494	+0.056	.001	.001	3	7
GBM	UTRN →	+0.309	+0.061	.007	<.001	3	7
LSCC	KANK2_S540 →	+0.643	+0.046	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903895 vs ZC3H14_S620 — OV

Explore this scatter interactively →