Negative regulation of IRE1-mediated unfolded protein response

Across TCGA cell cohorts, RNA activity of the Negative regulation of IRE1-mediated unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UFL1, FSD1, and PDSS2, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of IRE1-mediated unfolded protein response activity versus UFL1 in STOMACH (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	UFL1 →	+1.139	+0.283	<.001	.001	3	14
URINARY_TRACT	FSD1 →	-2.296	-0.163	.006	.003	3	7
SKIN	PDSS2 →	+0.671	+0.233	.006	.001	3	6
BLOOD_Leukemia	OSTM1 →	+0.632	+0.096	<.001	.007	3	6
BLOOD_Lymphoma	CD164 →	+0.935	+0.167	.006	.005	3	6
LIVER	SLC39A7 →	+0.952	+0.166	<.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903895 vs UFL1 — STOMACH

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