Regulation of IRE1-mediated unfolded protein response

Across TCGA cell cohorts, RNA activity of the Regulation of IRE1-mediated unfolded protein response pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COPS5, COPS4, and MAP2K1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COPS5 grouped by Regulation of IRE1-mediated unfolded protein response-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COPS5 →	-0.375	-0.507	<.001	.001	3	8
LUNG_SCLC	COPS4 →	-0.565	-0.180	.002	.002	2	6
UPPER_AERODIGESTIVE_TRACT	MAP2K1 →	+0.211	+0.349	.005	<.001	3	5
CNS	HIRA →	+0.207	+0.184	.003	.008	3	4
CNS	NFIC →	+0.235	+0.279	.001	<.001	3	3
CNS	MAP3K6 →	-0.292	-0.264	.001	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COPS5 by Regulation of IRE1-mediated unfolded protein response activity — LARGE_INTESTINE

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