Regulation of dendrite extension

Across TCGA cell cohorts, RNA activity of the Regulation of dendrite extension pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAT3, NOTCH2NLA, and CD81, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STAT3 grouped by Regulation of dendrite extension-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	STAT3 →	-0.681	-0.834	.003	.005	3	4
LARGE_INTESTINE	NOTCH2NLA →	-1.180	-0.938	<.001	<.001	3	4
LUNG_NSCLC_LUSC	CD81 →	-1.006	-1.325	<.001	<.001	3	4
OVARY	BAX →	-1.214	-1.042	.008	.004	3	4
KIDNEY	CCDC28A →	+0.773	+1.097	.003	.003	3	4
OESOPHAGUS	ARF3 →	-0.931	-1.860	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STAT3 by Regulation of dendrite extension activity — LARGE_INTESTINE

Explore this box plot interactively →