Positive regulation of cellular response to transforming growth factor beta stimulus

Across TCGA cell cohorts, RNA activity of the Positive regulation of cellular response to transforming growth factor beta stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELL3, KCTD20, and NACA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cellular response to transforming growth factor beta stimulus activity versus ELL3 in BREAST (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ELL3 →	+1.826	+0.216	.005	.002	2	6
LUNG_NSCLC_LUSC	KCTD20 →	+1.245	+0.349	.008	<.001	3	4
LIVER	NACA →	+0.665	+0.178	.003	.004	3	4
LUNG_NSCLC_LUSC	POLR1C →	+0.957	+0.421	.005	<.001	3	4
BLOOD_Myeloma	CMTR1 →	-0.579	-0.261	<.001	<.001	3	4
BLOOD_Myeloma	SAMD4B →	-1.047	-0.325	.009	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903846 vs ELL3 — BREAST

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