Negative regulation of cellular response to transforming growth factor beta stimulus

Across TCGA patient cohorts, RNA activity of the Negative regulation of cellular response to transforming growth factor beta stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DAB2, TANGO2, and FABP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cellular response to transforming growth factor beta stimulus activity versus DAB2 in GBM (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DAB2 →	+0.516	+0.085	<.001	<.001	3	6
CCRCC	TANGO2 →	+0.298	+0.095	<.001	<.001	3	5
BRCA	FABP4 →	+0.902	+0.063	<.001	.001	3	5
LUAD	SUGP2 →	-0.243	-0.134	<.001	<.001	3	5
LUAD	FBP1 →	+0.736	+0.149	<.001	<.001	2	6
LSCC	PPARG_S112 →	+0.588	+0.146	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903845 vs DAB2 — GBM

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