Negative regulation of cellular response to transforming growth factor beta stimulus

Across TCGA cell cohorts, RNA activity of the Negative regulation of cellular response to transforming growth factor beta stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UPP1, TCN2, and CLIP4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UPP1 grouped by Negative regulation of cellular response to transforming growth factor beta stimulus-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	UPP1 →	+2.346	+0.718	.001	.008	3	4
BREAST	TCN2 →	+1.077	+0.894	.004	.001	3	4
LUNG_SCLC	CLIP4 →	+1.916	+0.790	.002	.003	3	4
URINARY_TRACT	GPD2 →	-1.503	-0.350	<.001	.002	3	3
URINARY_TRACT	CENPU →	-1.152	-0.318	.002	<.001	3	3
SKIN	NCR3 →	+0.117	+0.393	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UPP1 by Negative regulation of cellular response to transforming growth factor beta stimulus activity — LUNG_SCLC

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